Cellular proteolysis and systemic inflammation during exacerbation in cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Breath isoprene during acute respiratory exacerbation in cystic fibrosis.
Patients with cystic fibrosis (CF) experience a combination of chronic systemic oxidative stress, generation of free radicals in the lungs due to a hyperimmune response and a diminished ability to scavenge free radicals secondary to malabsorption and increased consumption. The authors asked the question, "Does breath isoprene content reflect systemic oxidative stress?" The study involved 12 CF ...
متن کاملInflammation in Cystic Fibrosis
Mediators of Inflammation 5, 121-143 (1996) Inflammation in Cystic Fibrosis International Symposium
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BACKGROUND There is controversy about whether the inflammatory response observed in the cystic fibrosis (CF) lung occurs secondary to bacterial infection or is caused by a dysregulation of the inflammatory response associated with the basic cellular defect of CF. AIMS To study the inflammatory response in the gastrointestinal tract of children with CF; and to investigate whether there is incr...
متن کاملTargeting inflammation in cystic fibrosis.
disease, such as n –3 polyunsaturated fatty acids, receptor antagonists of the cysteinyl leukotrienes, macrolides, N acetylcysteine, and -1 antitrypsin have shown clinical efficacy or potential for clinical use, but to date no ideal anti-inflammatory agent for CF lung disease has been found [10] . Because of the notable side effects of broad-spectrum anti-inflammatory drugs, a more targeted app...
متن کاملInflammation and Airway Microbiota during Cystic Fibrosis Pulmonary Exacerbations
BACKGROUND Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during PEx. The relationship between airway microbiota, inflammation, and lung function during CF PEx is not well understood. OBJECTIVE To de...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2004
ISSN: 1569-1993
DOI: 10.1016/j.jcf.2004.07.003